ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Curr Biol 2019;29:813–822 e4.In vertebrates, puberty is the critical transitional step which leads to major somatic changes and the acquisition of the reproduction function. At the molecular level, puberty equates to the reactivation of the gonadotropic axis after a period of childhood quiescence, and hence increases sex steroid production. This reactivati...

Preface: As in previous years, in this year’s chapter we can present only 1% of the acquired publications (1326) according to our search criteria in PubMed in the Yearbook 2022. The last year has again been extremely exciting for the field of obesity and weight regulation, and it was a significant step into the future in terms of scientific output. The papers included in this chapter of the Yearbook are organized under these subheadings:• Genet...

Preface: We have been very happy to get around 1,500 papers out of our established search strategy in PubMed which have been saved in our 2020 yearbook EndNote database. We have then selected 16 papers (1%) which in our mind have been the most exciting ones. The highlights in this year chapter are publications about new gene variants with major effects on weight regulation, updates on pharmacological and surgical treatment of obesity in adolescents. The Yearbook chapter 2020 o...

We have been very happy to get around 2,000 papers out of our established search strategy in PubMed, which have been saved in our 2018 Yearbook EndNote database. We have then selected 20 papers (1%), which in our mind have been the most exciting ones. The highlights in this year’s chapter are publications about new adipokines - microRNAs released from adipose tissue and asprosin which has orexigenic and glucogenic activities - , about newly discovered genes causing monog...

P1. Preface: In analogy to previous years, in this year’s chapter we can only present 1.5% of the acquired publications (1384) according to our search criteria in Pubmed for the Yearbook 2023. The last year has again been extremely exciting for the field of obesity and weight regulation and it was a significant step into the future in terms of scientific output.Of particular importance are the new pharmacological therapeutic approaches for adolescen...

J Clin Endocrinol Metab. 2020 Oct 1;105(10):3243–3249 Abstract: https://pubmed.ncbi.nlm.nih.gov/32721016/In brief: X-linked hypophosphatemia (XLH) is the most common hereditary form of rickets and osteomalacia. The study used retrospective, pre-burosumab growth data from four different studies and constructed growth charts that demonstrate that the growth rate of children with...

PrefaceIn analogy to previous years, in this year’s chapter we can present only ~1% of the acquired publications according to our search criteria in Pubmed. The last year has again been extremely exciting for the field of obesity and weight regulation and it was a significant step into the future in terms of scientific output. Of course, one of the well-known phenomena of the past year has been a marked increase in child and adolescent body weights ...

Nature, 2020. 580, 511–516.https://www.nature.com/articles/s41586-020-2199-7 The authors identify in mice a population of neurons in the vagal ganglia and brainstem that are activated by the direct delivery of sugar but not artificial sweeteners to the gut. They genetically engineered changes in this gut-to-brain circuit. Silencing of synaptic activity in this circuit prevented...

To read the full abstract: Thyroid. 2019;29:595–606.Here, ultrastructural analysis of primary cilia in human thyroid follicles revealed a direct relationship between frequency and length of primary cilia and the functional state of the individual follicle in normal compared to hyperfunctioning thyroid tissues.Primary cilia are present in many different tissues...

Preface: We have been very happy to get around 1,500 papers out of our established search strategy in PubMed which have been saved in our 2019 yearbook EndNote database. We have then selected 15 papers (1%) which in our mind have been the most exciting ones. The highlights in this year’s chapter are publications about the genetic architecture of human thinness, a new hypoleptinemic leptin-responsive form of obesity, and early childhood BMI related to sustained risk of obe...